Clinical Pharmacy & Pharmacogenomics Life

the New England Journal of La-Di-Science 2012;11: 008-011

Antibody-Drug Conjugates (ADCs): A Brief Introduction

Wind Chang

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來　跟小風念一次：Docetaxal (doe se TAKS el)

今天因緣際會下　被學妹問到這一題...

Dexamethasone 與 Docetaxel 併用，主要可以預防：

(A) 低血壓 (hypotension)
(B) 水腫 (edema)

臨床上，一般認為，帶有 HER2-(+) 腫瘤屬於較嚴重的表現型，並代表其治療成效可能較差。

Clinically, HER2-positive tumors are associated with a more aggressive phenotype and poor outcomes.

人類上皮細胞生長因子受體 (human epidermal growth factor receptor, EGFR) 一共由四個單元組成：HER1 (又稱 EGFR), HER2, HER3 與 HER4。訊息傳遞便是藉由這些單元的兩兩偶合 (dimerization) 而產生，而偶合又可分為由不同單元異質間的偶合 (heterdimerization) 以及由相同單元組成的同質偶合 (homodimerization)。其中，HER2-HER3 的異質偶合在 PI3K–Akt–mTOR 之活化扮演了重要的角色，而此路徑與血管新生 (angiogenesis)、細胞存活、遷移 (migration)、凋亡 (apoptosis) 和增生 (proliferation) 具有極大的關係 [1-2]。

The human epidermal growth factor receptor (EGFR) family is composed of four members: HER1 or EGFR, HER2, HER3, and HER4. Signal transduction occurs as a result of receptor dimerization between members of the HER family either as heterodimerization (different receptors) or homodimerization (two of the same receptor). The HER2–HER3 heterodimer is particularly critical for activation of the phosphatidylinositol 3-kinase (PI3K)–Akt–mammalian target of rapamycin (mTOR) pathway, which in turn is able to influence other critical pathways driving angiogenesis, cell survival, migration, apoptosis, and proliferation [1-2].

New England Journal of Wind  2011 Jan;1(3): 6-10

Target Therapy & Monoclonal Antibodies

Wei-Lun Chang